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Evolution Detector (downloadable here) is a DNA sequence analysis program aimed at simplifying the process of detecting mutations from serially sampled DNA sequences using codon substitution models. The program is designed for use in fields such as virology, genomics and experimental evolution e.g. to detect drug resistance mutations in pathogens.

The current version of the program, which has been successfully tested on Windows 7-11, as well as on Linux via Wine, provides access to an implementation of Seoighe et al.'s (2007) model of directional selection. The program takes paired DNA sequences and branch lengths as input. It then performs likelihood ratio tests. The results from these tests can then be used to infer directional positive selection, as detailed in the user manual (accessible through the program's Help menu after installation).

 

Downloading and Installing Evolution Detector

To install Evolution Detector on Windows, simply download the setup file (Evolution Detector.exe) from the Releases page, execute it and follow installation instructions. If any errors occur during or after installation, please contact the developer at dev@evolutiondetector.com. In case the program fails to start due to a missing dll file, please install the latest version of Microsoft Visual C++ Redistributable and see if this solves the error before contacting the developer.

To run the program on Linux, you need to install Wine first, then use it to run Evolution Detector.exe.

 

References

Seoighe, C., Ketwaroo, F., Pillay, V., Scheffler, K., Wood, N., Zvelebil, R. D. M., Martinson, N., McIntyre, J., Morris, L., and Hide, W. (2007). A model of directional selection applied to the evolution of drug resistance in HIV-1. Molecular Biology and Evolution, 24:1025-1031.